Insulin degludec

Hypersensitivity. Hypoglycaemic episodes.

Patient with infections, fever, diseases affecting the adrenal, pituitary and thyroid gland, and those at risk for hypokalaemia. Not intended for treatment of diabetic ketoacidosis. Hepatic and renal impairment. Children. Lactation. Patient Counselling Rotate injection sites within the same body region and use a new needle for each injection. This drug may cause hypoglycaemia which may impair ability to concentrate or react, if affected, do not drive or operate machinery. Monitoring Parameters Closely monitor plasma glucose levels (especially during transfer from other insulin product); HbA_1c (at least twice yearly), electrolytes, lipid profile, renal and hepatic function, weight. Assess for signs of hypoglycaemia.

Significant: Lipodystrophy, hypoglycaemia, hypokalaemia, formation of insulin antibodies. Gastrointestinal disorders: Gastroenteritis, diarrhoea. General disorders and administration site conditions: Inj site reactions (e.g. haematoma, swelling, erythema), peripheral oedema. Immune system disorders: Urticaria. Investigations: Weight gain. Nervous system disorders: Headache. Respiratory, thoracic and mediastinal disorders: Nasopharyngitis, upper respiratory infection, sinusitis.
Potentially Fatal: Severe hypoglycaemia, severe allergic reactions, including anaphylaxis.

Risk of fluid retention and CHF when given with peroxisome proliferator-activated receptor (PPAR)-γ agonists (e.g. pioglitazone). Increased risk of hypoglycaemia with oral antidiabetic agents, glucagon-like peptide-1 (GLP-1) receptor agonists, ACE inhibitors, MAOIs, salicylates, sodium-glucose cotransporter 2 (SGLT2) inhibitors, sulfonamides, and anabolic steroids. Decreased glucose lowering effect with oral contraceptives, glucocorticoids, thiazides, thyroid hormones, growth hormone, sympathomimetics, glucagon, niacin, protease inhibitors, danazol. Somatostatin analogues (e.g. octreotide, lanreotide) may either increase or decrease insulin requirement. Beta-blockers, clonidine, guanethidine, lithium and reserpine may mask the symptoms of hypoglycaemia.

Insulin Preparations

A10AE06 - insulin degludec ; Belongs to the class of long-acting insulins and analogues for injection. Used in the treatment of diabetes.